As you age, your natural nicotinamide adenine dinucleotide (NAD+) levels decline. This leaves less energy for your body to maintain a youthful appearance and function. NAD+ is a coenzyme that forms a part of all living cells in your body and is fundamental to your quality of life.
A coenzyme is a helper molecule that attaches to other enzymes to produce positive health outcomes every day. NAD+ plays two important roles in your body. It helps:
- Us to metabolise the nutrients from food to turn them into energy
- The proteins to regulate other biological functions.
These functions are vital to the health of our DNA and for managing circadian rhythms to keep us healthier over the long term. But, as we age, our levels of NAD+ decline. A 2012 study , on ageing skin, demonstrated that beauty truly does come from within. It established that replacing the loss of NAD+ was vital to the ageing process.
Another study in 2014 supported this. It found that the combination of activating sirtuins and NAD+ therapy can be effective for anti-ageing.
An example of the decline of NAD+ in your system is that by the time you are 50, you will only have about half the natural NAD+ levels you did when young. By the time you reach 80, you will only have only between 1 to 10% of NAD+ levels left. So, it is important to replace your NAD+ levels for a longer life.
Using NAD+ IV therapy replenishes the levels in your system. It prevents DNA damage, chemical stress, failing mitochondria and inflammation throughout your body. At the same time, it repairs DNA and benefits your cells to promote longevity.
How NAD+ affects ageing
NAD+ was first discovered in 1906 and scientific understanding of its importance has been evolving ever since.
NAD+ divides into two parts. One part is the is the nicotinamide which your system recycles. The other is ADP-ribose which joins with a protein to repair cells. Poly ADP-ribose polymerases (PARPs) were then discovered. These are enzymes that organise the attachment of ADP-ribose components to proteins using NAD+ as the underlying layer. These key functions repair DNA, maintain genome stability and regulate changes to your DNA. PARPs are like sirtuins, which are also proteins, in that they need NAD+ to function correctly.
Sirtuins regulate your cellular health and ageing. They do this by protecting your DNA and managing inflammation. These proteins depend on NAD+ to turn on and off protective pathways that lead to age related diseases. Sirtuins are often called the longevity genes and the level of NAD+ in your system regulates how effectively they work.
Role of NR as a precursor to NAD+
Scientists inadvertently discovered nicotinamide riboside (NR) as an efficient precursor to NAD+ to boost its effectiveness. You can get NAD+ from foods made up of amino acids (like dairy and meats). These are not as effective as NR as a precursor to NAD+. NR is vitamin-like and can prolong life. Scientific studies have shown NR increases the lifespan of old mice by 5%. When given NR as a precursor to NAD+ near the end of their lives, it prolonged their lives.